Journal of Yeungnam Medical Science

Sung Bae Park

2 Articles

Impact of calcineurin inhibitors on rat glioma cells viability: Jeong Hun Seong, Woo Yeong Park, Jin Hyuk Paek, Sung Bae Park, Seungyeup Han, Kyo-Cheol Mun, Kyubok Jin; Yeungnam Univ J Med. 2019;36(2):105-108. Published online January 21, 2019; DOI: https://doi.org/10.12701/yujm.2019.00108

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Background
Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of CNIs by focusing on the viability of glioma cells.
Methods
Glioma cells were treated with several concentrations of CNIs for 24 hours at 37 ℃ and their cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Results
Exposure to 0, 0.25, 0.5, 2.5, 5.0, and 10.0 mM concentrations respectively showed 100%, 64.3%, 61.3%, 68.1%, 62.4%, and 68.6% cell viability for cyclosporine and 100%, 38.6%, 40.8%, 43.7%, 37.8%, and 43.0% for tacrolimus. The direct toxic effect of tacrolimus on glioma cell viability was stronger than that of cyclosporine at the same concentration.
Conclusion
CNIs can cause neurological side effects by directly exerting cytotoxic effects on brain cells. Therefore, we should carefully monitor the neurologic symptoms and level of CNIs in kidney transplant patients.

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Tacrolimus-Induced Neurotoxicity After Transplant: A Literature Review
Paige Verona, Jocelyn Edwards, Kassidy Hubert, Federica Avorio, Vincenzina Lo Re, Roberta Di Stefano, Anna Carollo, Heather Johnson, Alessio Provenzani
Drug Safety.2024; 47(5): 419. CrossRef

Ocular manifestations in a patient with de novo Fabry disease: You Hyun Lee, Kyu Young Shim, Sung Bae Park, Yu Cheol Kim; Yeungnam Univ J Med. 2018;35(2):232-235. Published online December 31, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.2.232

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Abstract PDF

Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

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Implications of Corneal Refractive Surgery in Patients with Fabry Disease
Majid Moshirfar, Nour Bundogji, Alyson N. Tukan, Yasmyne C. Ronquillo
Ophthalmology and Therapy.2022; 11(3): 925. CrossRef

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